|
KMID : 0043320120350101723
|
|
Archives of Pharmacal Research
2012 Volume.35 No. 10 p.1723 ~ p.1732
|
|
|
Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors
|
|
Zhu Yong
Chen Xin
Wu Zeng
Zheng Yixuan
Chen Yadong
Tang Weifang
Lu Tao
|
|
|
Abstract
|
|
|
|
A series of diaryl ether hydroxamic acids were synthesized for the first time and evaluated for the HDAC biology and antiproliferative activity. The structures of these new hydroxamic acids derivatives were confirmed by IR, 1H-NMR and mass spectrum. Some of these compounds showed micro molar activity in the HDAC inhibitory assay and against four cancer cell lines.
|
|
|
KEYWORD
|
|
|
HDAC inhibitors, Diaryl ether, Hydroxamic acid, Design, Synthesis, Antiproliferative activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|